AKT1 is detected as a mutational cancer driver in 1 cancer type: Breast carcinoma and in the PAN-cancer analysis
| AKT1 |
|---|
| Ensembl id ENSG00000142208 |
| Mutated samples
Coding Sequence 65 (1.0%) Protein Affecting 52 (0.8%) |
| Mode of action Activating |
| Known driver Yes |
| Cancer type | Signals (Biases) |
|---|---|
| BRCA | CFR |
| PAN |
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AKT1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.
| Cancer type | Driver | Mutated samples (CS) | Mutated samples (PAM) | % Mutated samples (PAM) |
|---|---|---|---|---|
| Breast carcinoma | Yes | 32 | 31 | 2.70 |
| Cutaneous melanoma | Yes | 11 | 4 | 1.08 |
| Uterine corpus endometrioid carcinoma | Yes | 4 | 3 | 1.30 |
| Lung adenocarcinoma | Yes | 2 | 2 | 0.51 |
| Renal clear cell carcinoma | Yes | 2 | 2 | 0.48 |
| Head and neck squamous cell carcinoma | Yes | 3 | 2 | 0.53 |
| Stomach adenocarcinoma | No | 2 | 2 | 1.24 |
| Prostate adenocarcinoma | No | 1 | 1 | 0.41 |
| Medulloblastoma | No | 1 | 1 | 0.48 |
| Lung squamous cell carcinoma | No | 1 | 1 | 0.57 |
| Pancreas adenocarcinoma | No | 1 | 1 | 0.47 |
| Small cell lung carcinoma | No | 1 | 1 | 1.45 |
| Glioblastoma multiforme | No | 1 | 1 | 0.26 |
| Bladder carcinoma | No | 1 | 0 | 0.00 |
| Thyroid carcinoma | No | 1 | 0 | 0.00 |
| Colorectal adenocarcinoma | No | 1 | 0 | 0.00 |
Choose a transcript:
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.
| Variant Locus | Samples | AA pos | AA change | Consequence |
|---|