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AKT1 is detected as a mutational cancer driver in 1 cancer type: Breast carcinoma and in the PAN-cancer analysis

AKT1
Ensembl id ENSG00000142208
Mutated samples
Coding Sequence 65 (1.0%)
Protein Affecting 52 (0.8%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
BRCA CFR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AKT1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 32 31 2.70
Cutaneous melanoma Yes 11 4 1.08
Uterine corpus endometrioid carcinoma Yes 4 3 1.30
Lung adenocarcinoma Yes 2 2 0.51
Renal clear cell carcinoma Yes 2 2 0.48
Head and neck squamous cell carcinoma Yes 3 2 0.53
Stomach adenocarcinoma No 2 2 1.24
Prostate adenocarcinoma No 1 1 0.41
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 1 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Bladder carcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence