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AKT1 BRCA ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
14:104780214:T E17K missense_variant 1.00 76
14:104776711:T Q79K missense_variant 0.99 3
14:104780108:C L52R missense_variant 0.96 3
14:104780214:G E17Q missense_variant 1.00 0
14:104780214:A E17* stop_gained 1.00 0
14:104780216:T G16E missense_variant 1.00 0
14:104780216:A G16V missense_variant 1.00 0
14:104780216:G G16A missense_variant 1.00 0
14:104780213:C E17G missense_variant 1.00 0
14:104780213:G E17A missense_variant 1.00 0
14:104780213:A E17V missense_variant 1.00 0
14:104776711:C Q79E missense_variant 0.99 0
14:104780202:G T21P missense_variant 0.99 0
14:104780202:C T21A missense_variant 0.99 0
14:104780202:A T21S missense_variant 0.99 0
14:104780210:C Y18C missense_variant 0.99 0
14:104780210:G Y18S missense_variant 0.99 0
14:104780106:G N53H missense_variant 0.99 0
14:104780106:C N53D missense_variant 0.99 0
14:104780106:A N53Y missense_variant 0.99 0
14:104780210:A Y18F missense_variant 0.99 0
14:104780135:C Q43R missense_variant 0.99 0
14:104780135:A Q43L missense_variant 0.99 0
14:104780135:G Q43P missense_variant 0.99 0
14:104780168:G D32A missense_variant 0.99 0
14:104780168:C D32G missense_variant 0.99 0
14:104780168:A D32V missense_variant 0.99 0
14:104776701:A T82I missense_variant 0.99 0
14:104776701:C T82S missense_variant 0.99 0
14:104776701:T T82N missense_variant 0.99 0
14:104776686:T T87N missense_variant 0.99 0
14:104776686:C T87S missense_variant 0.99 0
14:104776686:A T87I missense_variant 0.99 0
14:104780111:T P51H missense_variant 0.99 0
14:104780112:T P51T missense_variant 0.99 0
14:104780112:C P51A missense_variant 0.99 0
14:104780112:A P51S missense_variant 0.99 0
14:104780111:C P51R missense_variant 0.99 0
14:104780111:A P51L missense_variant 0.99 0
14:104776744:A P68S missense_variant 0.99 0
14:104776744:C P68A missense_variant 0.99 0
14:104776744:T P68T missense_variant 0.99 0
14:104776765:C Q61E missense_variant 0.99 0
14:104776765:T Q61K missense_variant 0.99 0
14:104776752:T T65K missense_variant 0.99 0
14:104776752:C T65R missense_variant 0.99 0
14:104776752:A T65M missense_variant 0.99 0
14:104776731:C T72S missense_variant 0.99 0
14:104776731:T T72N missense_variant 0.99 0
14:104776731:A T72I missense_variant 0.99 0
14:104780090:C A58G missense_variant 0.99 0
14:104780090:T A58E missense_variant 0.99 0
14:104780090:A A58V missense_variant 0.99 0
14:104780093:C V57G missense_variant 0.99 0
14:104780093:G V57A missense_variant 0.99 0
14:104780093:T V57E missense_variant 0.99 0
14:104780099:G F55S missense_variant 0.96 0
14:104780099:C F55C missense_variant 0.96 0
14:104780097:T S56T missense_variant 0.96 0
14:104780099:T F55Y missense_variant 0.96 0
14:104780097:G S56P missense_variant 0.96 0
14:104780097:C S56A missense_variant 0.96 0
14:104780108:T L52H missense_variant 0.96 0
14:104780108:G L52P missense_variant 0.96 0
14:104780197:A W22C missense_variant 0.93 0
14:104780197:G W22C missense_variant 0.93 0
14:104780198:A W22L missense_variant 0.93 0
14:104780198:G W22S missense_variant 0.93 0
14:104776719:G R76P missense_variant 0.91 0
14:104776716:A C77F missense_variant 0.91 0
14:104776716:G C77S missense_variant 0.91 0
14:104776716:T C77Y missense_variant 0.91 0
14:104776719:A R76L missense_variant 0.91 0
14:104776719:T R76H missense_variant 0.91 0
14:104776757:A M63I missense_variant 0.91 0
14:104776757:G M63I missense_variant 0.91 0
14:104776757:T M63I missense_variant 0.91 0
14:104776767:A C60F missense_variant 0.91 0
14:104776767:G C60S missense_variant 0.91 0
14:104776767:T C60Y missense_variant 0.91 0
14:104776713:T L78Q missense_variant 0.90 0
14:104776713:C L78R missense_variant 0.90 0
14:104776713:G L78P missense_variant 0.90 0
14:104776711:A Q79* stop_gained 0.89 0
14:104776695:T I84N missense_variant 0.88 0
14:104776695:G I84T missense_variant 0.88 0
14:104776695:C I84S missense_variant 0.88 0
14:104775770:G V106A missense_variant 0.88 0
14:104775770:T V106E missense_variant 0.88 0
14:104775770:C V106G missense_variant 0.88 0
14:104776768:T C60S missense_variant 0.88 0
14:104780100:T F55I missense_variant 0.88 0
14:104776768:G C60R missense_variant 0.88 0
14:104780160:C F35V missense_variant 0.88 0
14:104780160:G F35L missense_variant 0.88 0
14:104780160:T F35I missense_variant 0.88 0
14:104780100:C F55V missense_variant 0.88 0
14:104780100:G F55L missense_variant 0.88 0
14:104776768:C C60G missense_variant 0.88 0
14:104775792:G W99R missense_variant 0.87 0
14:104775792:C W99G missense_variant 0.87 0
14:104775792:T W99R missense_variant 0.87 0
14:104780184:C F27V missense_variant 0.86 0
14:104780187:G Y26H missense_variant 0.86 0
14:104780187:T Y26N missense_variant 0.86 0
14:104780184:T F27I missense_variant 0.86 0
14:104780184:G F27L missense_variant 0.86 0
14:104780187:C Y26D missense_variant 0.86 0
14:104780193:A P24S missense_variant 0.85 0
14:104780096:T S56Y missense_variant 0.85 0
14:104780096:C S56C missense_variant 0.85 0
14:104780096:A S56F missense_variant 0.85 0
14:104776737:T P70H missense_variant 0.85 0
14:104776737:C P70R missense_variant 0.85 0
14:104780124:C Q47E missense_variant 0.85 0
14:104780124:T Q47K missense_variant 0.85 0
14:104776737:A P70L missense_variant 0.85 0
14:104780193:C P24A missense_variant 0.85 0
14:104780193:T P24T missense_variant 0.85 0
14:104776681:T H89N missense_variant 0.85 0
14:104780201:A T21I missense_variant 0.85 0
14:104780201:C T21S missense_variant 0.85 0
14:104780201:T T21N missense_variant 0.85 0
14:104776681:C H89D missense_variant 0.85 0
14:104776681:A H89Y missense_variant 0.85 0
14:104775777:T Q104K missense_variant 0.85 0
14:104775777:C Q104E missense_variant 0.85 0
14:104776765:A Q61* stop_gained 0.85 0
14:104775776:A Q104L missense_variant 0.83 0
14:104775780:G I103L missense_variant 0.83 0
14:104775780:C I103V missense_variant 0.83 0
14:104775780:A I103F missense_variant 0.83 0
14:104775776:G Q104P missense_variant 0.83 0
14:104775776:C Q104R missense_variant 0.83 0
14:104792600:A R15L missense_variant 0.81 0
14:104792600:G R15P missense_variant 0.81 0
14:104792600:T R15Q missense_variant 0.81 0
14:104780126:A D46V missense_variant 0.80 0
14:104780126:G D46A missense_variant 0.80 0
14:104780126:C D46G missense_variant 0.80 0
14:104792598:G G16R missense_variant 0.80 0
14:104792598:A G16W missense_variant 0.80 0
14:104792598:T G16R missense_variant 0.80 0
14:104780133:T D44N missense_variant 0.79 0
14:104780133:A D44Y missense_variant 0.79 0
14:104780133:G D44H missense_variant 0.79 0
14:104792599:C R15R splice_region_variant 0.68 0
14:104792599:A R15R splice_region_variant 0.68 0
14:104792599:G R15R splice_region_variant 0.68 0
14:104780198:T W22* stop_gained 0.53 0
14:104780197:T W22* stop_gained 0.53 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(BRCA) Breast adenocarcinoma BRCA 0.76 0.11