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BoostDM

Through this web application you can either query or download the predictions and explanations produced by BoostDM for all the point mutations mapping to canonical transcripts in a collection of cancer genes and specific tumor-type contexts for which models with sufficiently high quality are available.


BoostDM is a method to score all possible point mutations (single base substitutions) in cancer genes for their potential to be involved in tumorigenesis. The method is based on the analysis of observed mutations in sequenced tumors and their site-by-site annotation with relevant features. The compendium of cancer genes and the mutational features for each cancer gene across malignancies have been derived from the systematic analysis of tens of thousands of tumor samples (www.intogen.org). Other relevant features have been collected from public databases. The method has been developed for the analysis presented in this preprint. A complete description of the method can be found there.

Search for a gene

or a particular mutation

Cancer genes available
Selected cancer driver genes with, at least, one reliable tumor type specific model.
Gene Models
AKT1 1
AMER1 1
APC 1
AR 1
ARID1A 2
ARID2 3
ATM 1
ATRX 3
AXIN1 1
BRAF 7
CARD11 3
CASP8 1
CDH1 1
CDKN2A 9
CHD4 1
CIC 2
CREBBP 3
CTNNB1 4
DDX3X 1
DNMT3A 3
EGFR 5
ERCC2 1
ESR1 1
EZH2 1
FAM46C 1
FAT1 1
FBXW7 2
FGFR3 1
FOXA1 2
IDH1 3
KDM6A 1
KMT2C 2
KMT2D 5
KRAS 10
MAP2K4 1
MEF2B 3
MYD88 2
NF1 4
NFE2L2 4
NRAS 5
P2RY8 1
PBRM1 2
PIK3CA 12
PIK3R1 1
PPP2R1A 1
PTEN 6
RB1 3
SF3B1 3
SGK1 2
SMAD4 4
SPOP 1
STK11 2
TCF7L2 1
TP53 32
VHL 2