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AKT1 14:104776765:A (Q61*) × BRCA ×
Driver potential information
Model BoostDM class BoostDM score
(BRCA) Breast adenocarcinoma Driver 0.85
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 0.00 -0.77 Medium negative
Linear Clustering in Cancer Type (LCT) 0.00 0.00 Non-significant
Linear Clustering (LC) 0.00 0.00 Non-significant
3D Clustering in Cancer Type (3CT) 0.00 -0.14 Medium negative
3D clustering (3C) 0.00 0.00 Non-significant
Recurrent in PFAM Domain (DOM) 1.00 0.47 Medium positive
Recurrent in PFAM Domain v2 (DOM2) 0.00 0.00 Non-significant
PhyloP 100-way Score (PHYLOP) 8.04 0.75 Medium positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 0.00 -0.29 Medium negative
Consequence Type: Nonsense (NONSENSE) 1.00 0.00 Non-significant
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant
Consequence Type: Synonymous (SYNONYMOUS) 0.00 0.00 Non-significant