IntOGen - XPO1 gene cancer mutations

XPO1 is detected as a mutational cancer driver

XPO1 reports

Methods
Mutation distribution

Gene details

XPO1
Ensembl ID ENSG00000082898 Transcript ID ENST00000401558 Protein ID ENSP00000384863
Cancer types where is driver 4 Cohorts where is driver 9 Mutated samples 35 Mutations 349
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence