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VCAN has not been detected as a mutational cancer driver

VCAN
Ensembl id ENSG00000038427
Mutated samples
Coding Sequence 251 (3.7%)
Protein Affecting 200 (2.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all VCAN gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 54 44 11.92
Lung adenocarcinoma No 29 23 5.88
Stomach adenocarcinoma No 18 17 10.56
Head and neck squamous cell carcinoma No 18 17 4.53
Lung squamous cell carcinoma No 19 16 9.20
Breast carcinoma No 13 10 0.87
Uterine corpus endometrioid carcinoma No 11 10 4.35
Bladder carcinoma No 9 9 9.18
Colorectal adenocarcinoma No 13 8 3.49
Esophageal carcinoma No 9 7 4.79
Renal clear cell carcinoma No 9 6 1.44
Serous ovarian adenocarcinoma No 8 5 1.58
Neuroblastoma No 6 4 1.90
Small cell lung carcinoma No 4 4 5.80
Glioblastoma multiforme No 5 4 1.06
Multiple myeloma No 4 3 4.35
Prostate adenocarcinoma No 4 2 0.82
Hepatocarcinoma No 4 2 2.22
Pancreas adenocarcinoma No 3 2 0.93
Non small cell lung carcinoma No 2 2 6.45
Acute myeloid leukemia No 2 1 0.51
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 4 1 0.34
Lower grade glioma No 1 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence