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USP6 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma

USP6
Ensembl id ENSG00000129204
Mutated samples
Coding Sequence 116 (1.7%)
Protein Affecting 84 (1.2%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
CM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all USP6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 43 35 9.49
Lung adenocarcinoma No 10 9 2.30
Lung squamous cell carcinoma No 9 8 4.60
Head and neck squamous cell carcinoma No 7 6 1.60
Glioblastoma multiforme No 5 5 1.32
Breast carcinoma No 3 3 0.26
Neuroblastoma No 4 3 1.43
Renal clear cell carcinoma No 4 2 0.48
Uterine corpus endometrioid carcinoma No 6 2 0.87
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 2 1 1.02
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Stomach adenocarcinoma No 6 1 0.62
Colorectal adenocarcinoma No 2 1 0.44
Esophageal carcinoma No 4 1 0.68
Non small cell lung carcinoma No 1 0 0.00
Serous ovarian adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence