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TOP2A is detected as a mutational cancer driver

TOP2A reports

Gene details
TOP2A
Ensembl ID ENSG00000131747
Transcript ID ENST00000423485
Protein ID ENSP00000411532
Cancer types where is driver 1
Cohorts where is driver 1
Mutated samples 6
Mutations 271
Mode of action Activating
Known driver False
Method signals per Cancer Type
Cancer type Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Consequence