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TMEM104 has not been detected as a mutational cancer driver

TMEM104
Ensembl id ENSG00000109066
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 22 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TMEM104 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 7 1.90
Stomach adenocarcinoma No 3 3 1.86
Colorectal adenocarcinoma No 3 2 0.87
Bladder carcinoma No 5 1 1.02
Acute myeloid leukemia No 2 1 0.51
Breast carcinoma No 5 1 0.09
Lung squamous cell carcinoma No 3 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 4 1 0.24
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Head and neck squamous cell carcinoma No 3 1 0.27
Esophageal carcinoma No 2 1 0.68
Lung adenocarcinoma No 2 0 0.00
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence