IntOGen - TET2 gene cancer mutations

TET2 is detected as a mutational cancer driver

TET2 reports

Methods
Mutation distribution

Gene details

TET2
Ensembl ID ENSG00000168769 Transcript ID ENST00000540549 Protein ID ENSP00000442788
Cancer types where is driver 8 Cohorts where is driver 10 Mutated samples 53 Mutations 600
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence