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TENM4 has not been detected as a mutational cancer driver

TENM4
Ensembl id ENSG00000149256
Mutated samples
Coding Sequence 232 (3.4%)
Protein Affecting 157 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TENM4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 69 51 13.82
Lung adenocarcinoma No 24 17 4.35
Lung squamous cell carcinoma No 14 13 7.47
Breast carcinoma No 17 12 1.05
Uterine corpus endometrioid carcinoma No 17 11 4.78
Stomach adenocarcinoma No 10 7 4.35
Bladder carcinoma No 6 5 5.10
Renal clear cell carcinoma No 7 5 1.20
Colorectal adenocarcinoma No 6 5 2.18
Head and neck squamous cell carcinoma No 7 5 1.33
Glioblastoma multiforme No 5 5 1.32
Esophageal carcinoma No 6 4 2.74
Hepatocarcinoma No 7 3 3.33
Serous ovarian adenocarcinoma No 3 3 0.95
Prostate adenocarcinoma No 4 2 0.82
Pancreas adenocarcinoma No 4 2 0.93
Thyroid carcinoma No 2 2 0.62
Neuroblastoma No 2 2 0.95
Acute lymphocytic leukemia No 2 2 1.64
Lower grade glioma No 1 1 0.59
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 13 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence