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SPTAN1 is detected as a mutational cancer driver in 2 cancer types: Breast carcinoma, Head and neck squamous cell carcinoma and in the PAN-cancer analysis

SPTAN1
Ensembl id ENSG00000197694
Mutated samples
Coding Sequence 157 (2.3%)
Protein Affecting 101 (1.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
BRCA F
HNSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SPTAN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 14 13 1.13
Head and neck squamous cell carcinoma Yes 15 12 3.20
Lung squamous cell carcinoma Yes 7 4 2.30
Glioblastoma multiforme Yes 4 3 0.79
Esophageal carcinoma Yes 5 3 2.05
Small cell lung carcinoma Yes 2 2 2.90
Cutaneous melanoma No 26 14 3.79
Lung adenocarcinoma No 14 10 2.56
Bladder carcinoma No 14 8 8.16
Stomach adenocarcinoma No 20 8 4.97
Uterine corpus endometrioid carcinoma No 11 7 3.04
Renal clear cell carcinoma No 5 5 1.20
Serous ovarian adenocarcinoma No 5 5 1.58
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 2 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 2 1 0.31
Multiple myeloma No 4 1 1.45
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 3 1 0.44
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence