SPOP is detected as a mutational cancer driver in 2 cancer types: Prostate adenocarcinoma, Uterine corpus endometrioid carcinoma and in the PAN-cancer analysis

Ensembl id ENSG00000121067
Mutated samples
Coding Sequence 64 (0.9%)
Protein Affecting 55 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SPOP gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate adenocarcinoma Yes 23 22 9.05
Uterine corpus endometrioid carcinoma Yes 15 15 6.52
Cutaneous melanoma Yes 7 3 0.81
Head and neck squamous cell carcinoma Yes 4 3 0.80
Stomach adenocarcinoma Yes 3 2 1.24
Lung adenocarcinoma No 1 1 0.26
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 1 1 0.09
Lung squamous cell carcinoma No 1 1 0.57
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 2 1 0.34
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence