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SMAD3 has not been detected as a mutational cancer driver

SMAD3
Ensembl id ENSG00000166949
Mutated samples
Coding Sequence 47 (0.7%)
Protein Affecting 36 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SMAD3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Colorectal adenocarcinoma No 5 5 2.18
Lung adenocarcinoma No 5 4 1.02
Cutaneous melanoma No 7 4 1.08
Uterine corpus endometrioid carcinoma No 5 4 1.74
Bladder carcinoma No 4 3 3.06
Breast carcinoma No 2 2 0.17
Lung squamous cell carcinoma No 3 2 1.15
Head and neck squamous cell carcinoma No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Stomach adenocarcinoma No 2 1 0.62
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence