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SLIT3 has not been detected as a mutational cancer driver

SLIT3
Ensembl id ENSG00000184347
Mutated samples
Coding Sequence 190 (2.8%)
Protein Affecting 124 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SLIT3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 61 40 10.84
Lung adenocarcinoma No 23 15 3.84
Glioblastoma multiforme No 12 10 2.64
Lung squamous cell carcinoma No 13 9 5.17
Uterine corpus endometrioid carcinoma No 12 9 3.91
Head and neck squamous cell carcinoma No 10 6 1.60
Renal clear cell carcinoma No 5 5 1.20
Small cell lung carcinoma No 5 5 7.25
Chronic lymphocytic leukemia No 13 4 1.38
Colorectal adenocarcinoma No 5 4 1.75
Breast carcinoma No 5 3 0.26
Serous ovarian adenocarcinoma No 3 3 0.95
Stomach adenocarcinoma No 4 3 1.86
Bladder carcinoma No 3 2 2.04
Non small cell lung carcinoma No 2 2 6.45
Hepatocarcinoma No 8 1 1.11
Lower grade glioma No 1 1 0.59
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Medulloblastoma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence