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SIN3A mutations in 8 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Lung squamous cell carcinoma, Renal clear cell carcinoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma, Small cell lung carcinoma, Head and neck squamous cell carcinoma, Glioblastoma multiforme

SIN3A
Ensembl id ENSG00000169375
Mutated samples
Coding Sequence 92 (1.4%)
Protein Affecting 70 (1.0%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SIN3A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 7 7 4.35
Lung squamous cell carcinoma Yes 7 5 2.87
Lung adenocarcinoma Yes 4 4 1.02
Head and neck squamous cell carcinoma Yes 5 4 1.07
Renal clear cell carcinoma Yes 4 2 0.48
Serous ovarian adenocarcinoma Yes 3 2 0.63
Small cell lung carcinoma Yes 4 2 2.90
Glioblastoma multiforme Yes 2 2 0.53
Cutaneous melanoma No 21 17 4.61
Uterine corpus endometrioid carcinoma No 14 10 4.35
Breast carcinoma No 5 5 0.44
Esophageal carcinoma No 5 5 3.42
Bladder carcinoma No 1 1 1.02
Medulloblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 1 1 0.44
Diffuse B cell lymphoma No 2 1 4.35
Hepatocarcinoma No 3 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence