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SH2B3 is detected as a mutational cancer driver in 1 cancer type: Acute lymphocytic leukemia

SH2B3
Ensembl id ENSG00000111252
Mutated samples
Coding Sequence 28 (0.4%)
Protein Affecting 13 (0.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
ALL F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SH2B3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Acute lymphocytic leukemia Yes 2 2 1.64
Cutaneous melanoma No 5 2 0.54
Prostate adenocarcinoma No 1 1 0.41
Lung adenocarcinoma No 2 1 0.26
Acute myeloid leukemia No 1 1 0.51
Breast carcinoma No 1 1 0.09
Uterine corpus endometrioid carcinoma No 1 1 0.43
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 2 1 0.62
Head and neck squamous cell carcinoma No 2 1 0.27
Hepatocarcinoma No 3 0 0.00
Lung squamous cell carcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Thyroid carcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence