RUNX1 is detected as a mutational cancer driver in 2 cancer types: Acute myeloid leukemia, Breast carcinoma and in the PAN-cancer analysis
| RUNX1 |
|---|
| Ensembl id ENSG00000159216 |
| Mutated samples
Coding Sequence 103 (1.5%) Protein Affecting 63 (0.9%) |
| Mode of action Loss of function |
| Known driver Yes |
| Cancer type | Signals (Biases) |
|---|---|
| AML | CFR |
| BRCA | FR |
| PAN |
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RUNX1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.
| Cancer type | Driver | Mutated samples (CS) | Mutated samples (PAM) | % Mutated samples (PAM) |
|---|---|---|---|---|
| Breast carcinoma | Yes | 31 | 27 | 2.35 |
| Acute myeloid leukemia | Yes | 18 | 18 | 9.18 |
| Uterine corpus endometrioid carcinoma | Yes | 3 | 3 | 1.30 |
| Head and neck squamous cell carcinoma | Yes | 4 | 3 | 0.80 |
| Cutaneous melanoma | Yes | 12 | 2 | 0.54 |
| Stomach adenocarcinoma | Yes | 3 | 2 | 1.24 |
| Colorectal adenocarcinoma | Yes | 2 | 2 | 0.87 |
| Esophageal carcinoma | No | 4 | 4 | 2.74 |
| Lung adenocarcinoma | No | 2 | 1 | 0.26 |
| Bladder carcinoma | No | 2 | 1 | 1.02 |
| Hepatocarcinoma | No | 5 | 0 | 0.00 |
| Lung squamous cell carcinoma | No | 1 | 0 | 0.00 |
| Renal clear cell carcinoma | No | 1 | 0 | 0.00 |
| Non small cell lung carcinoma | No | 1 | 0 | 0.00 |
| Chronic lymphocytic leukemia | No | 11 | 0 | 0.00 |
| Pylocytic astrocytoma | No | 2 | 0 | 0.00 |
| Glioblastoma multiforme | No | 1 | 0 | 0.00 |
Choose a transcript:
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.
| Variant Locus | Samples | AA pos | AA change | Consequence |
|---|