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RUNX1 is detected as a mutational cancer driver in 2 cancer types: Acute myeloid leukemia, Breast carcinoma and in the PAN-cancer analysis

RUNX1
Ensembl id ENSG00000159216
Mutated samples
Coding Sequence 103 (1.5%)
Protein Affecting 63 (0.9%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
AML CFR
BRCA FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RUNX1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 31 27 2.35
Acute myeloid leukemia Yes 18 18 9.18
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Head and neck squamous cell carcinoma Yes 4 3 0.80
Cutaneous melanoma Yes 12 2 0.54
Stomach adenocarcinoma Yes 3 2 1.24
Colorectal adenocarcinoma Yes 2 2 0.87
Esophageal carcinoma No 4 4 2.74
Lung adenocarcinoma No 2 1 0.26
Bladder carcinoma No 2 1 1.02
Hepatocarcinoma No 5 0 0.00
Lung squamous cell carcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 11 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence