IntOGen - ROBO2 gene cancer mutations

ROBO2 is detected as a mutational cancer driver

ROBO2 reports

Methods
Mutation distribution

Gene details

ROBO2
Ensembl ID ENSG00000185008 Transcript ID ENST00000487694 Protein ID ENSP00000417335
Cancer types where is driver 9 Cohorts where is driver 12 Mutated samples 62 Mutations 1,196
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence