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RNF6 has not been detected as a mutational cancer driver

RNF6
Ensembl id ENSG00000127870
Mutated samples
Coding Sequence 36 (0.5%)
Protein Affecting 27 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RNF6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 11 8 2.17
Breast carcinoma No 6 5 0.44
Head and neck squamous cell carcinoma No 3 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 2 2 2.04
Esophageal carcinoma No 3 2 1.37
Lung adenocarcinoma No 1 1 0.26
Pancreas adenocarcinoma No 1 1 0.47
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence