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RNF43 has not been detected as a mutational cancer driver

RNF43
Ensembl id ENSG00000108375
Mutated samples
Coding Sequence 72 (1.1%)
Protein Affecting 52 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RNF43 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma No 14 13 8.07
Lung adenocarcinoma No 7 7 1.79
Uterine corpus endometrioid carcinoma No 8 6 2.61
Cutaneous melanoma No 8 4 1.08
Lung squamous cell carcinoma No 5 3 1.72
Renal clear cell carcinoma No 5 3 0.72
Esophageal carcinoma No 5 3 2.05
Prostate adenocarcinoma No 2 2 0.82
Breast carcinoma No 2 2 0.17
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 2 2 0.63
Glioblastoma multiforme No 3 2 0.53
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 3 1 0.44
Medulloblastoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Head and neck squamous cell carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence