IntOGen - RNF213 gene cancer mutations

RNF213 is detected as a mutational cancer driver

RNF213 reports

Methods
Mutation distribution

Gene details

RNF213
Ensembl ID ENSG00000173821 Transcript ID ENST00000582970 Protein ID ENSP00000464087
Cancer types where is driver 11 Cohorts where is driver 11 Mutated samples 40 Mutations 1,510
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence