RASGEF1A has not been detected as a mutational cancer driver

Ensembl id ENSG00000198915
Mutated samples
Coding Sequence 24 (0.4%)
Protein Affecting 18 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RASGEF1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate adenocarcinoma No 3 3 1.23
Cutaneous melanoma No 4 3 0.81
Bladder carcinoma No 2 2 2.04
Lung squamous cell carcinoma No 3 2 1.15
Stomach adenocarcinoma No 3 2 1.24
Head and neck squamous cell carcinoma No 2 2 0.53
Esophageal carcinoma No 2 2 1.37
Breast carcinoma No 1 1 0.09
Serous ovarian adenocarcinoma No 1 1 0.32
Lung adenocarcinoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence