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RAG2 has not been detected as a mutational cancer driver

RAG2
Ensembl id ENSG00000175097
Mutated samples
Coding Sequence 179 (2.6%)
Protein Affecting 53 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RAG2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 50 18 4.88
Small cell lung carcinoma No 10 5 7.25
Lung adenocarcinoma No 23 4 1.02
Lung squamous cell carcinoma No 11 4 2.30
Breast carcinoma No 11 3 0.26
Uterine corpus endometrioid carcinoma No 7 3 1.30
Glioblastoma multiforme No 9 3 0.79
Hepatocarcinoma No 5 2 2.22
Head and neck squamous cell carcinoma No 7 2 0.53
Esophageal carcinoma No 12 2 1.37
Bladder carcinoma No 3 1 1.02
Pancreas adenocarcinoma No 2 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 2 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Diffuse B cell lymphoma No 1 1 4.35
Prostate adenocarcinoma No 6 0 0.00
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Lower grade glioma No 2 0 0.00
Stomach adenocarcinoma No 4 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence