PRRX1 mutations in 5 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Stomach adenocarcinoma, Head and neck squamous cell carcinoma

Ensembl id ENSG00000116132
Mutated samples
Coding Sequence 42 (0.6%)
Protein Affecting 28 (0.4%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PRRX1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 10 6 1.63
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Stomach adenocarcinoma Yes 3 3 1.86
Lung adenocarcinoma Yes 3 2 0.51
Head and neck squamous cell carcinoma Yes 4 2 0.53
Breast carcinoma No 7 6 0.52
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 2 1 1.02
Lung squamous cell carcinoma No 1 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence