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PPM1D is detected as a mutational cancer driver in 1 cancer type: Thyroid carcinoma

PPM1D
Ensembl id ENSG00000170836
Mutated samples
Coding Sequence 31 (0.5%)
Protein Affecting 24 (0.4%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
THCA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PPM1D gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Thyroid carcinoma Yes 5 5 1.55
Lung adenocarcinoma No 5 5 1.28
Uterine corpus endometrioid carcinoma No 3 3 1.30
Breast carcinoma No 3 2 0.17
Head and neck squamous cell carcinoma No 2 2 0.53
Medulloblastoma No 1 1 0.48
Cutaneous melanoma No 3 1 0.27
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 4 1 0.26
Acute lymphocytic leukemia No 1 1 0.82
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence