PKM has not been detected as a mutational cancer driver

Ensembl id ENSG00000067225
Mutated samples
Coding Sequence 28 (0.4%)
Protein Affecting 18 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PKM gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 11 4 1.08
Lung squamous cell carcinoma No 3 3 1.72
Head and neck squamous cell carcinoma No 4 3 0.80
Lung adenocarcinoma No 2 2 0.51
Uterine corpus endometrioid carcinoma No 2 2 0.87
Breast carcinoma No 1 1 0.09
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Stomach adenocarcinoma No 2 1 0.62
Thyroid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence