IntOGen - PIK3CA gene cancer mutations

PIK3CA is detected as a mutational cancer driver

PIK3CA reports

Methods
In-silico saturation
Mutation distribution

Gene details

PIK3CA
Ensembl ID ENSG00000121879 Transcript ID ENST00000263967 Protein ID ENSP00000263967
Cancer types where is driver 36 Cohorts where is driver 87 Mutated samples 2,157 Mutations 2,453
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.

Model	Mutations	Driver mutations	Driver mutations (%)
BLCA (Bladder cancer)	87	60	68.97
BRCA (Breast adenocarcinoma)	190	131	68.95
CESC (Cervix squamous cancer)	29	24	82.76
CNS (Central nervous system cancer)	15	14	93.33
COREAD (Colorectal adenocarcinoma)	106	81	76.42
ESCA (Esophageal cancer)	39	28	71.79
G (Glioma)	78	63	80.77
HNSC (Head and neck squamous cell carcinoma)	45	31	68.89
LUNG_CANCER (Lung cancer)	6	4	66.67
NSCLC (Non-small cell lung cancer)	82	59	71.95
ST (Stomach adenocarcinoma)	45	35	77.78
UCEC (Endometrial cancer)	101	76	75.25

Observed mutations in tumors

Plot
Table

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence