Top
PDZD2 has not been detected as a mutational cancer driver

PDZD2
Ensembl id ENSG00000133401
Mutated samples
Coding Sequence 256 (3.8%)
Protein Affecting 176 (2.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PDZD2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 79 51 13.82
Stomach adenocarcinoma No 21 15 9.32
Breast carcinoma No 18 14 1.22
Lung squamous cell carcinoma No 17 14 8.05
Head and neck squamous cell carcinoma No 17 12 3.20
Lung adenocarcinoma No 17 11 2.81
Renal clear cell carcinoma No 10 7 1.68
Uterine corpus endometrioid carcinoma No 10 7 3.04
Bladder carcinoma No 8 6 6.12
Prostate adenocarcinoma No 6 5 2.06
Serous ovarian adenocarcinoma No 5 5 1.58
Small cell lung carcinoma No 5 5 7.25
Colorectal adenocarcinoma No 5 5 2.18
Esophageal carcinoma No 6 4 2.74
Glioblastoma multiforme No 4 3 0.79
Hepatocarcinoma No 8 2 2.22
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 2 2 1.18
Medulloblastoma No 2 1 0.48
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 8 1 0.34
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 2 1 0.82
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence