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NUP98 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

NUP98
Ensembl id ENSG00000110713
Mutated samples
Coding Sequence 127 (1.9%)
Protein Affecting 77 (1.1%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NUP98 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 28 18 4.88
Breast carcinoma Yes 12 10 0.87
Stomach adenocarcinoma Yes 10 7 4.35
Lung adenocarcinoma Yes 7 6 1.53
Bladder carcinoma Yes 7 5 5.10
Lung squamous cell carcinoma Yes 7 3 1.72
Prostate adenocarcinoma Yes 2 2 0.82
Renal clear cell carcinoma Yes 3 2 0.48
Colorectal adenocarcinoma Yes 3 2 0.87
Esophageal carcinoma Yes 5 2 1.37
Uterine corpus endometrioid carcinoma No 11 5 2.17
Head and neck squamous cell carcinoma No 8 4 1.07
Hepatocarcinoma No 2 2 2.22
Small cell lung carcinoma No 3 2 2.90
Glioblastoma multiforme No 8 2 0.53
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 2 1 0.48
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Acute lymphocytic leukemia No 1 1 0.82
Chronic lymphocytic leukemia No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence