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NUP214 has not been detected as a mutational cancer driver

NUP214
Ensembl id ENSG00000126883
Mutated samples
Coding Sequence 114 (1.7%)
Protein Affecting 91 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NUP214 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 29 24 6.50
Lung adenocarcinoma No 18 16 4.09
Breast carcinoma No 11 9 0.78
Uterine corpus endometrioid carcinoma No 13 7 3.04
Stomach adenocarcinoma No 8 7 4.35
Head and neck squamous cell carcinoma No 6 5 1.33
Lung squamous cell carcinoma No 4 4 2.30
Bladder carcinoma No 3 3 3.06
Renal clear cell carcinoma No 3 2 0.48
Thyroid carcinoma No 3 2 0.62
Serous ovarian adenocarcinoma No 2 2 0.63
Glioblastoma multiforme No 2 2 0.53
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 2 1 1.11
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence