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NTRK2 is detected as a mutational cancer driver in 1 cancer type: Lung adenocarcinoma

NTRK2
Ensembl id ENSG00000148053
Mutated samples
Coding Sequence 94 (1.4%)
Protein Affecting 59 (0.9%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
LUAD F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NTRK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 13 13 3.32
Cutaneous melanoma No 18 11 2.98
Breast carcinoma No 8 7 0.61
Stomach adenocarcinoma No 5 5 3.11
Uterine corpus endometrioid carcinoma No 6 4 1.74
Small cell lung carcinoma No 4 4 5.80
Bladder carcinoma No 4 3 3.06
Medulloblastoma No 4 3 1.43
Multiple myeloma No 2 2 2.90
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 4 1 0.27
Esophageal carcinoma No 5 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 7 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 8 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence