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NRAS is detected as a mutational cancer driver in 8 cancer types: Lung adenocarcinoma, Acute myeloid leukemia, Thyroid carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Chronic lymphocytic leukemia plus in 2 more and in the PAN-cancer analysis

NRAS
Ensembl id ENSG00000213281
Mutated samples
Coding Sequence 234 (3.4%)
Protein Affecting 209 (3.1%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
LUAD C
AML CFR
THCA CFR
CM CFR
UCEC F
CLL CF
MM CF
COREAD CFR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NRAS gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 103 100 27.10
Thyroid carcinoma Yes 26 26 8.07
Colorectal adenocarcinoma Yes 17 17 7.42
Multiple myeloma Yes 16 16 23.19
Acute myeloid leukemia Yes 15 15 7.65
Lung adenocarcinoma Yes 9 7 1.79
Uterine corpus endometrioid carcinoma Yes 9 6 2.61
Chronic lymphocytic leukemia Yes 4 4 1.38
Breast carcinoma Yes 6 3 0.26
Acute lymphocytic leukemia Yes 3 3 2.46
Bladder carcinoma Yes 4 2 2.04
Neuroblastoma Yes 2 2 0.95
Serous ovarian adenocarcinoma Yes 3 2 0.63
Stomach adenocarcinoma No 5 2 1.24
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 1 1 0.57
Lower grade glioma No 1 1 0.59
Glioblastoma multiforme No 1 1 0.26
Prostate adenocarcinoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Head and neck squamous cell carcinoma No 2 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence