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NOTCH3 has not been detected as a mutational cancer driver

NOTCH3
Ensembl id ENSG00000074181
Mutated samples
Coding Sequence 140 (2.1%)
Protein Affecting 101 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NOTCH3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 21 5.69
Head and neck squamous cell carcinoma No 21 17 4.53
Uterine corpus endometrioid carcinoma No 11 10 4.35
Lung adenocarcinoma No 9 8 2.05
Renal clear cell carcinoma No 6 6 1.44
Lung squamous cell carcinoma No 7 5 2.87
Colorectal adenocarcinoma No 5 5 2.18
Breast carcinoma No 6 3 0.26
Lower grade glioma No 4 3 1.78
Serous ovarian adenocarcinoma No 5 3 0.95
Small cell lung carcinoma No 5 3 4.35
Prostate adenocarcinoma No 3 2 0.82
Hepatocarcinoma No 2 2 2.22
Bladder carcinoma No 2 2 2.04
Neuroblastoma No 2 2 0.95
Stomach adenocarcinoma No 5 2 1.24
Glioblastoma multiforme No 5 2 0.53
Esophageal carcinoma No 4 2 1.37
Medulloblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Thyroid carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence