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NLRP13 has not been detected as a mutational cancer driver

NLRP13
Ensembl id ENSG00000173572
Mutated samples
Coding Sequence 167 (2.5%)
Protein Affecting 119 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NLRP13 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 70 43 11.65
Lung adenocarcinoma No 20 17 4.35
Lung squamous cell carcinoma No 16 15 8.62
Breast carcinoma No 9 7 0.61
Head and neck squamous cell carcinoma No 9 6 1.60
Small cell lung carcinoma No 5 5 7.25
Serous ovarian adenocarcinoma No 4 3 0.95
Colorectal adenocarcinoma No 3 3 1.31
Esophageal carcinoma No 4 3 2.05
Pancreas adenocarcinoma No 2 2 0.93
Uterine corpus endometrioid carcinoma No 5 2 0.87
Lower grade glioma No 2 2 1.18
Stomach adenocarcinoma No 3 2 1.24
Glioblastoma multiforme No 6 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 1 1 1.45
Pylocytic astrocytoma No 1 1 0.99
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence