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NIPBL has not been detected as a mutational cancer driver

NIPBL
Ensembl id ENSG00000164190
Mutated samples
Coding Sequence 161 (2.4%)
Protein Affecting 122 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NIPBL gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 21 5.69
Lung adenocarcinoma No 13 13 3.32
Stomach adenocarcinoma No 18 13 8.07
Head and neck squamous cell carcinoma No 13 11 2.93
Breast carcinoma No 11 10 0.87
Uterine corpus endometrioid carcinoma No 13 9 3.91
Lung squamous cell carcinoma No 10 7 4.02
Lower grade glioma No 5 5 2.96
Serous ovarian adenocarcinoma No 5 5 1.58
Bladder carcinoma No 6 4 4.08
Renal clear cell carcinoma No 8 4 0.96
Esophageal carcinoma No 5 4 2.74
Prostate adenocarcinoma No 3 3 1.23
Thyroid carcinoma No 2 2 0.62
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 2 1 0.47
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence