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MYO5A has not been detected as a mutational cancer driver

MYO5A
Ensembl id ENSG00000197535
Mutated samples
Coding Sequence 107 (1.6%)
Protein Affecting 76 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MYO5A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 10 9 0.78
Cutaneous melanoma No 12 9 2.44
Lung adenocarcinoma No 12 8 2.05
Uterine corpus endometrioid carcinoma No 8 7 3.04
Head and neck squamous cell carcinoma No 8 6 1.60
Esophageal carcinoma No 7 6 4.11
Lung squamous cell carcinoma No 8 5 2.87
Stomach adenocarcinoma No 8 5 3.11
Colorectal adenocarcinoma No 4 4 1.75
Bladder carcinoma No 3 3 3.06
Non small cell lung carcinoma No 4 3 9.68
Lower grade glioma No 4 3 1.78
Renal clear cell carcinoma No 4 2 0.48
Serous ovarian adenocarcinoma No 3 2 0.63
Glioblastoma multiforme No 2 2 0.53
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence