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MYH11 mutations in 3 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Bladder carcinoma, Breast carcinoma, Stomach adenocarcinoma

MYH11
Ensembl id ENSG00000133392
Mutated samples
Coding Sequence 174 (2.6%)
Protein Affecting 126 (1.9%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MYH11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 15 12 1.05
Stomach adenocarcinoma Yes 6 5 3.11
Bladder carcinoma Yes 3 3 3.06
Cutaneous melanoma No 50 34 9.21
Lung adenocarcinoma No 18 14 3.58
Head and neck squamous cell carcinoma No 10 9 2.40
Lung squamous cell carcinoma No 11 8 4.60
Serous ovarian adenocarcinoma No 7 7 2.22
Colorectal adenocarcinoma No 9 7 3.06
Renal clear cell carcinoma No 9 6 1.44
Glioblastoma multiforme No 7 6 1.58
Uterine corpus endometrioid carcinoma No 11 5 2.17
Medulloblastoma No 4 2 0.95
Pancreas adenocarcinoma No 2 2 0.93
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Lower grade glioma No 1 1 0.59
Pylocytic astrocytoma No 1 1 0.99
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 3 1 0.68
Non small cell lung carcinoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence