IntOGen - MPL gene cancer mutations

MPL is detected as a mutational cancer driver

MPL reports

Methods
Mutation distribution

Gene details

MPL
Ensembl ID ENSG00000117400 Transcript ID ENST00000372470 Protein ID ENSP00000361548
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 4 Mutations 234
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence