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MICAL2 has not been detected as a mutational cancer driver

MICAL2
Ensembl id ENSG00000133816
Mutated samples
Coding Sequence 98 (1.4%)
Protein Affecting 66 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MICAL2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 29 22 5.96
Lung adenocarcinoma No 8 7 1.79
Bladder carcinoma No 7 6 6.12
Breast carcinoma No 6 5 0.44
Uterine corpus endometrioid carcinoma No 4 4 1.74
Stomach adenocarcinoma No 5 4 2.48
Renal clear cell carcinoma No 4 3 0.72
Glioblastoma multiforme No 5 3 0.79
Lung squamous cell carcinoma No 2 2 1.15
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 4 1 1.11
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 5 1 0.27
Chronic lymphocytic leukemia No 6 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
Esophageal carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence