IntOGen - MDM2 gene cancer mutations

MDM2 is detected as a mutational cancer driver

MDM2 reports

Methods
Mutation distribution

Gene details

MDM2
Ensembl ID ENSG00000135679 Transcript ID ENST00000258149 Protein ID ENSP00000258149
Cancer types where is driver 2 Cohorts where is driver 2 Mutated samples 5 Mutations 158
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence