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MAP2K1 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

MAP2K1
Ensembl id ENSG00000169032
Mutated samples
Coding Sequence 51 (0.8%)
Protein Affecting 39 (0.6%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
CM CF
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAP2K1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 24 19 5.15
Lung adenocarcinoma Yes 5 5 1.28
Stomach adenocarcinoma Yes 5 3 1.86
Lung squamous cell carcinoma Yes 3 2 1.15
Colorectal adenocarcinoma Yes 2 2 0.87
Head and neck squamous cell carcinoma No 4 4 1.07
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 2 1 0.09
Uterine corpus endometrioid carcinoma No 2 1 0.43
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence