Top
LZTR1 has not been detected as a mutational cancer driver

LZTR1
Ensembl id ENSG00000099949
Mutated samples
Coding Sequence 129 (1.9%)
Protein Affecting 67 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LZTR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma No 13 10 4.35
Cutaneous melanoma No 25 9 2.44
Glioblastoma multiforme No 11 9 2.37
Lung adenocarcinoma No 13 8 2.05
Breast carcinoma No 9 5 0.44
Stomach adenocarcinoma No 8 5 3.11
Head and neck squamous cell carcinoma No 11 5 1.33
Lung squamous cell carcinoma No 8 4 2.30
Serous ovarian adenocarcinoma No 6 3 0.95
Prostate adenocarcinoma No 3 1 0.41
Bladder carcinoma No 4 1 1.02
Medulloblastoma No 2 1 0.48
Renal clear cell carcinoma No 6 1 0.24
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 1 1 0.44
Acute lymphocytic leukemia No 2 1 0.82
Hepatocarcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence