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LRRK2 has not been detected as a mutational cancer driver

LRRK2
Ensembl id ENSG00000188906
Mutated samples
Coding Sequence 216 (3.2%)
Protein Affecting 173 (2.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRRK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 21 5.69
Lung squamous cell carcinoma No 24 20 11.49
Head and neck squamous cell carcinoma No 23 20 5.33
Stomach adenocarcinoma No 21 18 11.18
Lung adenocarcinoma No 18 17 4.35
Esophageal carcinoma No 14 11 7.53
Breast carcinoma No 12 9 0.78
Serous ovarian adenocarcinoma No 10 9 2.85
Uterine corpus endometrioid carcinoma No 11 8 3.48
Small cell lung carcinoma No 8 8 11.59
Renal clear cell carcinoma No 6 6 1.44
Bladder carcinoma No 6 5 5.10
Colorectal adenocarcinoma No 5 5 2.18
Pancreas adenocarcinoma No 4 3 1.40
Glioblastoma multiforme No 4 3 0.79
Prostate adenocarcinoma No 2 2 0.82
Medulloblastoma No 2 2 0.95
Non small cell lung carcinoma No 5 2 6.45
Acute lymphocytic leukemia No 3 2 1.64
Chronic lymphocytic leukemia No 1 1 0.34
Lower grade glioma No 1 1 0.59
Hepatocarcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence