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LRP1 has not been detected as a mutational cancer driver

LRP1
Ensembl id ENSG00000123384
Mutated samples
Coding Sequence 268 (3.9%)
Protein Affecting 193 (2.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 59 35 9.49
Uterine corpus endometrioid carcinoma No 21 16 6.96
Head and neck squamous cell carcinoma No 20 16 4.27
Lung adenocarcinoma No 23 15 3.84
Breast carcinoma No 16 13 1.13
Lung squamous cell carcinoma No 18 13 7.47
Stomach adenocarcinoma No 15 12 7.45
Bladder carcinoma No 11 10 10.20
Renal clear cell carcinoma No 13 10 2.40
Glioblastoma multiforme No 11 9 2.37
Esophageal carcinoma No 10 9 6.16
Serous ovarian adenocarcinoma No 8 7 2.22
Colorectal adenocarcinoma No 7 6 2.62
Lower grade glioma No 6 5 2.96
Prostate adenocarcinoma No 7 4 1.65
Thyroid carcinoma No 7 4 1.24
Pancreas adenocarcinoma No 3 2 0.93
Chronic lymphocytic leukemia No 2 2 0.69
Small cell lung carcinoma No 2 2 2.90
Hepatocarcinoma No 5 1 1.11
Neuroblastoma No 1 1 0.48
Acute lymphocytic leukemia No 1 1 0.82
Non small cell lung carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence