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LIFR has not been detected as a mutational cancer driver

LIFR
Ensembl id ENSG00000113594
Mutated samples
Coding Sequence 115 (1.7%)
Protein Affecting 85 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LIFR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 39 29 7.86
Colorectal adenocarcinoma No 12 11 4.80
Breast carcinoma No 11 8 0.70
Head and neck squamous cell carcinoma No 10 8 2.13
Uterine corpus endometrioid carcinoma No 5 4 1.74
Small cell lung carcinoma No 4 4 5.80
Lung squamous cell carcinoma No 3 3 1.72
Stomach adenocarcinoma No 4 3 1.86
Lung adenocarcinoma No 3 2 0.51
Renal clear cell carcinoma No 2 2 0.48
Non small cell lung carcinoma No 2 2 6.45
Serous ovarian adenocarcinoma No 2 2 0.63
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 4 1 1.11
Bladder carcinoma No 1 1 1.02
Chronic lymphocytic leukemia No 8 1 0.34
Diffuse B cell lymphoma No 1 1 4.35
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Thyroid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence