IntOGen - KRAS gene cancer mutations in BRCA

KRAS is detected as a mutational cancer driver in Invasive Breast Carcinoma

KRAS reports in Invasive Breast Carcinoma (BRCA)

Methods
Mutation distribution

Cancer type details

Invasive Breast Carcinoma
Cohorts 14 Samples 3,201 Mutations 19,887,724 Driver genes 117

Gene details

KRAS
Ensembl ID ENSG00000133703 Transcript ID ENST00000256078 Protein ID ENSP00000256078
Cohorts where is driver 2 Mutated samples 15 Mutated samples (%) 0.47 Mutations 18
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence