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KRAS is detected as a mutational cancer driver in 10 cancer types: Lung adenocarcinoma, Acute myeloid leukemia, Breast carcinoma, Pancreas adenocarcinoma, Uterine corpus endometrioid carcinoma, Chronic lymphocytic leukemia plus in 4 more and in the PAN-cancer analysis

KRAS
Ensembl id ENSG00000133703
Mutated samples
Coding Sequence 544 (8.0%)
Protein Affecting 533 (7.8%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
LUAD CFR
AML FR
BRCA CR
PAAD CF
UCEC CF
CLL C
MM CF
STAD CFR
COREAD CFR
ALL F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KRAS gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Pancreas adenocarcinoma Yes 185 185 86.45
Lung adenocarcinoma Yes 121 120 30.69
Colorectal adenocarcinoma Yes 103 103 44.98
Uterine corpus endometrioid carcinoma Yes 47 46 20.00
Multiple myeloma Yes 17 17 24.64
Stomach adenocarcinoma Yes 13 13 8.07
Acute myeloid leukemia Yes 9 8 4.08
Breast carcinoma Yes 9 7 0.61
Chronic lymphocytic leukemia Yes 5 5 1.72
Thyroid carcinoma Yes 3 3 0.93
Cutaneous melanoma Yes 5 3 0.81
Acute lymphocytic leukemia Yes 3 3 2.46
Lung squamous cell carcinoma Yes 2 2 1.15
Non small cell lung carcinoma Yes 2 2 6.45
Serous ovarian adenocarcinoma Yes 2 2 0.63
Glioblastoma multiforme Yes 2 2 0.53
Esophageal carcinoma No 8 6 4.11
Head and neck squamous cell carcinoma No 2 2 0.53
Renal clear cell carcinoma No 1 1 0.24
Lower grade glioma No 1 1 0.59
Pylocytic astrocytoma No 1 1 0.99
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence