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KIF5A has not been detected as a mutational cancer driver

KIF5A
Ensembl id ENSG00000155980
Mutated samples
Coding Sequence 107 (1.6%)
Protein Affecting 77 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KIF5A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 22 5.96
Uterine corpus endometrioid carcinoma No 14 11 4.78
Lung squamous cell carcinoma No 11 10 5.75
Lung adenocarcinoma No 12 9 2.30
Breast carcinoma No 10 8 0.70
Small cell lung carcinoma No 4 4 5.80
Head and neck squamous cell carcinoma No 7 3 0.80
Non small cell lung carcinoma No 2 2 6.45
Chronic lymphocytic leukemia No 2 2 0.69
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 2 2 1.24
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 3 1 0.68
Prostate adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Glioblastoma multiforme No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence