IntOGen - IKZF3 gene cancer mutations

IKZF3 is detected as a mutational cancer driver

IKZF3 reports

Methods
Mutation distribution

Gene details

IKZF3
Ensembl ID ENSG00000161405 Transcript ID ENST00000346872 Protein ID ENSP00000344544
Cancer types where is driver 3 Cohorts where is driver 4 Mutated samples 19 Mutations 309
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence